TABLE 2

Linear mixed-effect modeling results

The S.D. estimate of the intercept and residuals, respectively, represents the BSV and WSV for the log-transformed teriflunomide concentration metrics and partition coefficient. The 90% confidence intervals (90% CI) of the S.D. estimates have also been represented.

Intercept (BSV) S.D. Estimate (90% CI)Residuals (WSV) S.D. Estimate (90% CI)
Teriflunomide Concentration
 CD3+ T cells0.04 (<0.001–0.40)0.50 (0.36–0.65)
 CD3 MNC<0.001 (<0.001–0.50)0.56 (0.38–0.73)
 RBC0.45 (0.30–0.66)0.25 (0.18–0.40)
 Unbound plasma0.54 (0.40–0.75)0.14 (0.10–0.23)
 Total plasma0.53 (0.40–0.75)0.16 (0.11–0.26)
Teriflunomide partition coefficient
 Unbound to CD3+ T cells<0.001 (<0.001–0.10)0.13 (0.11–0.17)
 Unbound to CD3 MNC0.07 (<0.001–0.19)0.19 (0.13–0.26)
 Unbound to RBC3.72 (<0.001–7.11)6.00 (4.25–8.81)