TABLE 2

IC50 values (µM) for CUR, PIP, CAP and the manufacturer-recommended inhibitors against CYP1A2, CYP2C9, CYP2D6, and CYP3A4 isozymes activity

Data represent mean ± S.D. (n = 3).

P450 IsozymeIC50 (µM)Published IC50 (µM) for Inhibitor
CURPIPCAP
CYP1A2101.73 ± 10.07a14.19 ± 4.15b2.14 ± 0.22a,b0.26 for NPV (Nayadu et al., 2013)c
CYP2C914.58 ± 4.57a89.62 ± 9.17b11.95 ± 4.24a10.00 for SPZ (Zhang et al., 2008)d
CYP2D695.42 ± 12.09110.40 ± 3.2399.99 ± 5.880.50 for QDN (Kong et al., 2011)c
CYP3A411.93 ± 3.49a2.12 ± 0.45b1.84 ± 0.71b0.54 for KCZ (Trubetskoy et al., 2005a)e
  • a P < 0.05, significant difference to PIP.

  • b P < 0.05, significant difference to CUR.

  • c Recombinant human isozyme.

  • d Human liver microsomes.

  • e DPX-2 cell line.