TABLE 2

IC₅₀ values (µM) for CUR, PIP, CAP and the manufacturer-recommended inhibitors against CYP1A2, CYP2C9, CYP2D6, and CYP3A4 isozymes activity

Data represent mean ± S.D. (n = 3).

P450 Isozyme	IC₅₀ (µM)			Published IC₅₀ (µM) for Inhibitor
P450 Isozyme	CUR	PIP	CAP	Published IC₅₀ (µM) for Inhibitor
CYP1A2	101.73 ± 10.07^{^a}	14.19 ± 4.15^{^b}	2.14 ± 0.22^{^a}^,^{^b}	0.26 for NPV (Nayadu et al., 2013)^{^c}
CYP2C9	14.58 ± 4.57^{^a}	89.62 ± 9.17^{^b}	11.95 ± 4.24^{^a}	10.00 for SPZ (Zhang et al., 2008)^{^d}
CYP2D6	95.42 ± 12.09	110.40 ± 3.23	99.99 ± 5.88	0.50 for QDN (Kong et al., 2011)^{^c}
CYP3A4	11.93 ± 3.49^{^a}	2.12 ± 0.45^{^b}	1.84 ± 0.71^{^b}	0.54 for KCZ (Trubetskoy et al., 2005a)^{^e}