TABLE 3

Comparison of IC50 values for SC-mediated inhibition of P450 functional activity

IC50 values are expressed in µM.

CURPresent study(Volak et al., 2008)a(Appiah-Opong et al., 2007)b(Bamba et al., 2011)c(Oetari et al., 1996)d(Thapliyal and Maru, 2001)d
CYP3A411.9 ± 3.525.3 ± 1.416.3 ± 1.714.9 ± 1.4
CYP2C914.6 ± 4.613.5 ± 1.44.3 ± 0.86.0 ± 1.4
CYP1A2101.7 ± 10.195.4 ± 17.140.0 ± 12.7104.6 ± 22.129.6
CYP2D695.4 ± 12.163.6 ± 4.850.3 ± 2.0175.0 ± 47.0
PIPPresent study(Volak et al., 2008)a
CYP3A42.1 ± 0.55.5 ± 0.7 (CYP3A)
CYP1A214.2 ± 4.229.8 ± 3.6
CYP2C989.6 ± 9.240.7 ± 4.1
CYP2D6110.4 ± 3.2>50
CAPPresent study(Babbar et al., 2010)a(Zhang et al., 2012)a(Takanohashi et al., 2010)a
CYP3A41.8 ± 0.712–3827.221.5
CYP1A22.1 ± 0.22.1 ± 0.217.2
CYP2C911.9 ± 4.22.0 ± 0.26.1
CYP2D6100.0 ± 5.918 ± 531.5

  • ↵a Microsomes isolated from livers from human donors, curcuminoid extracts.

  • ↵b Recombinant P450 enzymes expressed in E. coli from donated cDNA plasmids.

  • ↵c BD Gentest enzyme high-throughput inhibitor screening kit.

  • ↵d Microsomes isolated from rodent livers.