TABLE 6

Prediction accuracy and bias in the prediction of clinical CYP3A4 inducers using HepatoCells

Substrate	Metrics	Endpoint	HepatoCells
Substrate	Metrics	Endpoint	Lot 2B	Lot 3A	Lot 3B
Midazolam and nonmidazolam	RMSE	Activity	0.34	0.33	0.31
	RMSE	mRNA	0.34	0.35	0.33
	GMFE	Activity	7.9	12.3	8.4
	GMFE	mRNA	6.5	13.0	20.1
Midazolam	RMSE	Activity	0.046	0.025	0.063
	RMSE	mRNA	0.088	0.070	0.034
	GMFE	Activity	1.3	1.2	1.6
	GMFE	mRNA	1.3	1.5	1.2
Nonmidazolam	RMSE	Activity	0.48	0.47	0.43
	RMSE	mRNA	0.48	0.49	0.47
	GMFE	Activity	71	207	62
	GMFE	mRNA	44	169	587