Geometric mean of pharmacokinetic parameters for LY2140023 and LY404039 after a single 80-mg dose of LY2140023 administered alone or with valacyclovir
Geometric mean (CV%) are presented for each parameter except where noted.
| Treatment | LY2140023 Parameters | LY404039 Parameters | ||
|---|---|---|---|---|
| LY2140023 80 mg | LY2140023 80 mg + Valacyclovir 1000 mg | LY2140023 80 mg | LY2140023 80 mg + Valacyclovir 1000 mg | |
| N | 20 | 20 | 20 | 20 |
| Cmax (ng/ml) | 307 (26) | 272 (30) | 477 (17) | 444 (23) |
| tmaxa (hour) | 3.00 (2.00–5.03) | 3.00 (1.25–6.00) | 4.00 (3.00–6.07) | 4.00 (2.50–6.00) |
| t1/2 (hour) | 1.92 (26) | 1.80 (24) | 3.05 (14) | 3.11 (16) |
| AUC(0-∞) (ng⋅h/ml) | 1330 (27) | 1210 (31) | 2600 (16) | 2490 (24) |
| CL/F (L/hour) | 60.2 (27) | 65.9 (31) | 19.7 (16) | 20.5 (24) |
| Vz/F (l) | 166 (27) | 171 (21) | 86.5 (24) | 92.2 (34) |
| Fe | 0.651 (15.9) | 0.595 (13.2) | ||
| CLr (l/h) | 12.8 (23.6) | 12.2 (25.0) | ||
↵a Median (Min–Max)