RIS cutoff value at 20% midazolam AUC change in HepatoCells and primary human hepatocytes
Primary human hepatocyte data were obtained from a previous study (Zhang et al., 2014).
| HepatoCells | Primary Human Hepatocytes | ||||
|---|---|---|---|---|---|
| Lot No. | RIS (Enzyme Activity) | RIS (mRNA) | Lot No. | RIS (Enzyme Activity) | RIS (mRNA) |
| Lot 2B | 0.12 | 0.20 | Lot 295 | 0.017 | 0.017 |
| Lot 3A | 0.19 | 0.30 | Lot 312 | 0.013 | 0.019 |
| Lot 3B | 0.20 | 0.19 | Lot 318 | 0.0078 | 0.011 |
| Mean | 0.17 | 0.23 | Mean | 0.013 | 0.016 |
| %CV | 25% | 26% | %CV | 37% | 27% |