| | | | µM | Km (µM) | Km (µM) | |
Therapeutics | | | | | | | |
Antibiotics | Cefotaxime | HEK293 cells | OAT2-546aa | | Unknown | Yes (549 and 717) | Yee et al., 2013 |
| Erythromycin | X. laevis oocytes | OAT2-548aa | 18.5 | Unknown | Unknown | Kobayashi et al., 2005b |
| Tetracycline | Mouse S2 RPTCs | Unknown | 440 | Unknown | Yes (556) | Babu et al., 2002 |
Antigout and uricosuric agents | Allopurinol | X. laevis oocytes | OAT2-548aa | | Unknown | Unknown | Kobayashi et al., 2005a |
Antimetabolites | 5-Fluorouracil | X. laevis oocytes | OAT2-548aa | 0.0538 | Unknown | Unknown | Kobayashi et al., 2005a |
| Methotrexate | Mouse S2 RPTCs | Unknown | | Yes (554 and 724) | Yes (10.9–70.6) | Sun et al., 2001 |
Antivirals | Acyclovir | HEK293 cells | OAT2-546aa | 94 | Yes (289–839) | Yes (416–772) | Cheng et al., 2012 |
| Ganciclovir | HEK293 cells | OAT2-546aa | 264 | Yes (896) | Unknown | Cheng et al., 2012 |
| PCV | HEK293 cells | OAT2-546aa | 284 | Unknown | Unknown | Cheng et al., 2012 |
Dietary Supplements and vitamins | Ascorbic acid (vitamin C) | X. laevis oocytes | OAT2-548aa | | Unknown | Unknown | Kobayashi et al., 2005a |
Diuretics | Bumetanide | X. laevis oocytes | OAT2-548aa | 7.52 | Yes | Yes (1.6) | Kobayashi et al., 2005a |
H2 receptor antagonists | Cimetidine | HEK293 cells | OAT2-546aa | | Yes | Unknown | Tahara et al., 2005 |
| Ranitidine | HEK293 cells | OAT2-546aa | 396 | Yes | Unknown | Tahara et al., 2005 |
Herbal medications | Tanshinol | HEK293 cells | OAT2-546aa | 859 | Yes (121) | Yes (1,888) | Jia et al., 2015 |
Methylxanthines | Theophylline (1,3-DMX) | X. laevis oocytes | OAT2-548aa | 12.6 | Unknown | Unknown | Kobayashi et al., 2005b |
| Xanthine | HEK293 cells | OAT2-546aa | | Unknown | Unknown | Yamada et al., 2014 |
Nonsteroidal anti-inflammatory drugs | Diclofenac | HEK293 cells | OAT2-546aa | 46.8 | No | No | Zhang et al., 2016 |
| Diclofenac acyl glucuronide | HEK293 cells | OAT2-546aa | 8.6 | Yes (60.2) | Yes (114) | Zhang et al., 2016 |
| Salicylic acid | Mouse S2 RPTCs | OAT2-539aa | | Yes | Yes | Igarashi et al., 2002 |
Nucleoside reverse transcriptase inhibitors | Zidovudine | Mouse S2 RPTCs | Unknown | 26.8 | Yes (45.9) | Yes (145) | Takeda et al., 2002 |
Taxanes | Paclitaxel | X. laevis oocytes | OAT2-548aa | 0.143 | Unknown | Unknown | Kobayashi et al., 2005a |
Topoisomerase Inhibitors | Irinotecan | HEK293 cells | OAT2-546aa | 42.4 | Unknown | Unknown | Marada et al., 2015 |
Endogenous compounds | | | | | | | |
Androgens | DHEA sulfate | X. laevis oocytes | OAT2-548aa | | Unknown | Unknown | Kobayashi et al., 2005a |
Estrogens | E3S | X. laevis oocytes | OAT2-548aa | | Unknown | Unknown | Kobayashi et al., 2005a |
None | 1-Methyl-4-phenylpyridinium | HEK293 cells | OAT2-546aa | | Unknown | Unknown | Shen et al., 2015 |
| cGMP | HEK293 cells | OAT2-546aa | 101 | Yes | Yes | Marada et al., 2015 |
| cGMP | HEK293 cells | OAT2-546aa | 88 | | | Cropp et al., 2008 |
| cGMP | HEK293 cells | OAT2-546aa | | | | Henjakovic et al., 2015 |
| Creatinine | HEK293 cells | OAT2-546aa | 795 | Unknown | Yes | Shen et al., 2015 |
| Creatinine | HEK293 cells | OAT2-546aa | 986 | | | Lepist et al., 2014 |
| Orotic acid | HEK293 cells | OAT2-546aa | 200 (rOat2) | Unknown | Unknown | Fork et al., 2011 |
| PAH | Other cells | Unknown | | Yes (3.1–60.3) | Yes (7.4 and 87.2) | Sun et al., 2001 |
| Uric acid | HEK293 cells | OAT2-546aa | | Unknown | Unknown | Henjakovic et al., 2015 |
Prostaglandins | Prostaglandin E2 | X. laevis oocytes | OAT2-548aa | | Unknown | Unknown | Kobayashi et al., 2005a |
| Prostaglandin F2 | Mouse S2 RPTCs | OAT2-539aa | 0.425 | Unknown | Unknown | Enomoto et al., 2002b |
| Prostaglandin F2 | HEK293 cells | OAT2-546aa | 45.5 | Unknown | Unknown | Jia et al., 2015 |
| Prostaglandin F2 | Other cells | unknown | | Unknown | Unknown | Nakagomi-Hagihara et al., 2007 |