Properties of human OAT1–3
| Transporter | Gene Symbol | Alternative Name | Chromosomal Localization | Protein Length | mRNA Tissue Distribution | Protein Tissue Distribution | Membrane Localization | Transporter Mechanism | Major References |
|---|---|---|---|---|---|---|---|---|---|
| aa | |||||||||
| OAT1 | SLC22A6 | NKT | 11q12.3 | 563 | Kidney > > brain, mammary gland, salivary gland, spleen, thymus, etc. | Kidney and choroid plexus | Basolateral | Organic anion-dicarboxylate exchanger | Burckhardt, 2012; Emami Riedmaier et al., 2012; Nigam et al., 2015 |
| OAT2 | SLC22A7 | Novel liver-specific transporter | 6p21.1 | 546, 548, 539 | Liver > kidney > > brain, stomach, ileum, uterus, mammary gland, etc. | Liver and kidney | Basolateral and apical in the kidney and unknown in the liver | Unknown | Cropp et al., 2008; Burckhardt, 2012; Emami Riedmaier et al., 2012; Hotchkiss et al., 2015 |
| OAT3 | SLC22A8 | ROCT | 11q12.3 | 542 | Kidney > > brain, spleen, uterus, etc. | Kidney, choroid plexus, and testes | Basolateral | Organic anion-dicarboxylate exchanger | Burckhardt, 2012; Emami Riedmaier et al., 2012; Nigam et al., 2015 |