Species differences of metabolite levels in plasma after oral administration
Australian public assessment report for vildagliptin, Department of Health and Ageing, Therapeutic Goods Administration, 2010 April. Available from: http://www.tga.gov.au/auspar/auspar-vildagliptin (accessed June 7, 2016).
Species | Metabolite (% of Total AUC) | |||
---|---|---|---|---|
Parental Vildagliptin | M15.3 | M20.2 | M20.7 | |
Human | 26 | 8.1 | 9.5 | 56 |
Mouse | 46 | Trace | 3.8 | 17 |
Rat | 40 | 0 | 11 | 42 |
Dog | 23 | 26 | 1.4 | 33 |
Rabbit | 22 | 53 | 0.9 | 7.4 |
Monkey | 20 | 0.8 | 72 | 4.9 |