AUC0–8 hours in three mouse groups following oral administration of vildagliptin (10 mg/kg)
| Group | Numbers | AUC0–8 hours (ng × h/mL) | |
|---|---|---|---|
| Vildagliptin | M20.7 | ||
| Control mice | 4 | 90 ± 14 | 26 ± 2.6 |
| Control mice + sitagliptin (1000 mg/kg) | 3 | 108 ± 21 | 8.5 ± 2.1** |
| STZ-induced diabetic mice (day7) | 3 | 68 ± 16 | 10 ± 0.8** |
↵** P < 0.01 versus control mice.