CYP3A4 and CYP2J2 reversible inhibition kinetic parameters for amiodarone, NDEA, dronedarone, and NDBD using rivaroxaban metabolite peak area ratio as a surrogate measurement of product formation
Data represent means ± S.D.
| P450 | Ki |
|---|---|
| μM | |
| CYP3A4 | |
| Amiodarone | 0.226 ± 0.050 |
| NDEA | 0.239 ± 0.053 |
| Dronedarone | 0.64 ± 0.045 |
| NDBD | 1.03 ± 0.053 |
| CYP2J2 | |
| Amiodarone | NA |
| NDEA | NA |
| Dronedarone | 0.93 ± 0.11 |
| NDBD | 2.53 ± 0.33 |
NA, not applicable.