Parameter | Venetoclax (n = 4) | M27 (n = 4) | Total Radioactivity (n = 4) |
---|---|---|---|
Tmax (h)a | 5 (4–8) | 12 (12–12) | 5 (4–10) |
Cmax (µg/ml) | 1.41 (30) | 0.28 (27) | 1.57 (26.8) |
t1/2 (h)b | 23.3 (4.4) | 58.8 (32) | 20.1 (68.7) |
AUCt (µg⋅h/ml) | 20.0 (35) | 14.9 (32) | — |
AUC∞ (µg⋅h/ml) | 20.1 (35) | 15.8 (32) | 35.4 (39.2) |
% AUCext | — | — | 10.5 (19.4) |
AUC0–48 h (µg-eq⋅h/ml) | — | — | 31.6 (38.4) |