TABLE 1

Mean (%CV) pharmacokinetic parameters of venetoclax, M27 metabolite and total radioactivity in plasma after a single oral dose of [14C]venetoclax

For total radioactivity, the units are µg-eq/ml for Cmax and µg-eq⋅h/ml for AUC.

ParameterVenetoclax (n = 4)M27 (n = 4)Total Radioactivity (n = 4)
Tmax (h)a5 (4–8)12 (12–12)5 (4–10)
Cmax (µg/ml)1.41 (30)0.28 (27)1.57 (26.8)
t1/2 (h)b23.3 (4.4)58.8 (32)20.1 (68.7)
AUCt (µg⋅h/ml)20.0 (35)14.9 (32)
AUC (µg⋅h/ml)20.1 (35)15.8 (32)35.4 (39.2)
% AUCext10.5 (19.4)
AUC0–48 h (µg-eq⋅h/ml)31.6 (38.4)
  • a Tmax is presented as median (min–max).

  • b Harmonic mean (%CV).