TABLE 2

Percentages of venetoclax and metabolites in human feces after a single oral dose of 200 mg (100 μCi) of [14C]venetoclax (n = 4)

Metabolites including M3, M4, M7, M10, M19, M22, M24, M25, M38, M39, M40, M41, M42, M43, M44, and M45 were detected by LC/MS.

MatrixFecesTotal
0–2424–4848–7272–9696–120120–144144–1680–168
h
Parent1.064.5710.132.260.831.290.6920.8
M2/M17/M33aMS/MS/NDMS/MS/0.81.710.83ND/MS/MSND/MS/MSND/MS/MS3.3
M5MS1.030.690.33MSMSMS2.0
M14NDND0.430.48MSNDND0.9
M16NDND6.352.37MSMSMS8.7
M18MS1.071.89NDNDMSND3.0
M23ND0.56MSNDNDNDND0.6
M27NDND1.190.15MSMSMS1.3
M30ND1.545.682.160.961.610.9312.9
M31NDMS2.210.86MSMSMS3.1
M32ND1.551.950.57MSMSMS4.1
M34NDMS6.683.211.713.491.8416.9
M35NDMS2.191.21NDMSMS3.4
M36NDMS2.74NDMSMSMS2.7
M37NDMS3.041.08MSMSMS4.1
Unk 3ND0.721.411.151.992.370.528.2
Unk 4NDNDND0.86NDNDND0.9
OthersNDNDND2.49NDNDND2.5
Total1.0611.848.320.05.498.763.9999.4
  • MS = detected by mass spec only; ND = not detected.

  • a M2/M17/M33 coelute, so data were reported together.