TABLE 5

Fi and T1/2inv of inversion calculated by AUC analysis, deconvolution method, and model analysis in control and AA rats

Results are expressed as the mean ± S.D. (n = 3).

ControlAA
AUC analysis (FiAUC)aDeconvolution method (FiDECON)bModel analysis (FiCOMP)cAUC analysis (FiAUC)aDeconvolution method (FiDECON)bModel analysis (FiCOMP)c
Fi0.47 ± 0.070.51 ± 0.130.52 ± 0.120.51 ± 0.080.53 ± 0.180.56 ± 0.05
T1/2inv (min)15.9 ± 4.429.7 ± 10.514.1 ± 3.425.8 ± 7.7
  • a FiAUC = AUCR→S/AUCS→S.

  • b Calculated using the deconvolution method.

  • c FiCOMP = kRS/k0(R) + kRS.

  • The em dashes indicate no value because of unidirectional chiral inversion of IB.