TABLE 1

Noncompartmental pharmacokinetic parameters of each enantiomer after intravenous administration of rac-IB

Results are expressed as the mean ± SD (n = 3).

Parameter	Control		AA
Parameter	R-IB	S-IB	R-IB	S-IB
T_1/2 (min)	35.7 ± 6.8	89.5 ± 37.1	30.7 ± 6.5	69.0 ± 17.0^{^b}
CL_tot (ml/min/kg)	3.70 ± 0.14	0.80 ± 0.27^{^b}	5.40 ± 0.71^{^a}	1.20 ± 0.31^{^b}
MRT (min)	32.7 ± 3.9	127 ± 51.9^{^b}	30.3 ± 5.7	97.5 ± 29.5^{^b}
Vd_ss (ml/kg)	120 ± 18	89 ± 10	165 ± 38	115 ± 21
AUC_0-∞ (μg∣min/ml)	2720 ± 103	14031 ± 4496^{^b}	1862 ± 230^{^a}	8597 ± 2350^{^b}

↵^a P < 0.05 compared with controls.
↵^b P < 0.05 compared with its antipode.