TABLE 2

Compartmental pharmacokinetic parameters of each enantiomer after intravenous administration of rac-IB

Results are expressed as the mean ± S.D. (n = 3).

Parameter	Control		AA
Parameter	R-IB	S-IB	R-IB	S-IB
V₁ (ml/kg)	63.1 ± 4.4	67.3 ± 9.9	86.0 ± 34.2	95.8 ± 18.3
V₂ (ml/kg)	56.4 ± 24.6	56.0 ± 23.2	80.3 ± 28.4	68.3 ± 29.9
CL_tot (ml/min/kg)	4.01 ± 0.40	1.46 ± 0.40^{^b}	6.16 ± 1.11^{^a}	2.19 ± 0.67^{^b}
CL_RS (ml/min/kg)	2.75 ± 0.39	―	3.96 ± 0.67^{^a}	―
CL_MET (ml/min/kg)	1.26 ± 0.09	1.46 ± 0.40	2.19 ± 0.55^{^a}	2.19 ± 0.67
k₀₍_R₎ (min⁻¹)	0.020 ± 0.001	―	0.024 ± 0.007	―
k₁₂ (min⁻¹)	0.072 ± 0.031	0.070 ± 0.035	0.059 ± 0.030	0.070 ± 0.035
k₂₁ (min⁻¹)	0.074 ± 0.024	0.062 ± 0.020	0.076 ± 0.019	0.083 ± 0.018
k₁₀ (min⁻¹)	0.064 ± 0.007	0.021 ± 0.003^{^b}	0.076 ± 0.017	0.023 ± 0.004^{^b}
k_RS (min⁻¹)	0.044 ± 0.007	―	0.052 ± 0.022	―

↵^a P < 0.05 compared with controls.
↵^b P < 0.05 compared with its antipode.
The em dashes indicate no value because of unidirectional chiral inversion of IB.