TABLE 2

Compartmental pharmacokinetic parameters of each enantiomer after intravenous administration of rac-IB

Results are expressed as the mean ± S.D. (n = 3).

ParameterControlAA
R-IBS-IBR-IBS-IB
V1 (ml/kg)63.1 ± 4.467.3 ± 9.986.0 ± 34.295.8 ± 18.3
V2 (ml/kg)56.4 ± 24.656.0 ± 23.280.3 ± 28.468.3 ± 29.9
CLtot (ml/min/kg)4.01 ± 0.401.46 ± 0.40b6.16 ± 1.11a2.19 ± 0.67b
CLRS (ml/min/kg)2.75 ± 0.393.96 ± 0.67a
CLMET (ml/min/kg)1.26 ± 0.091.46 ± 0.402.19 ± 0.55a2.19 ± 0.67
k0(R) (min−1)0.020 ± 0.0010.024 ± 0.007
k12 (min−1)0.072 ± 0.0310.070 ± 0.0350.059 ± 0.0300.070 ± 0.035
k21 (min−1)0.074 ± 0.0240.062 ± 0.0200.076 ± 0.0190.083 ± 0.018
k10 (min−1)0.064 ± 0.0070.021 ± 0.003b0.076 ± 0.0170.023 ± 0.004b
kRS (min−1)0.044 ± 0.0070.052 ± 0.022
  • a P < 0.05 compared with controls.

  • b P < 0.05 compared with its antipode.

  • The em dashes indicate no value because of unidirectional chiral inversion of IB.