TABLE 4

Compartmental pharmacokinetic parameters of each enantiomer after intravenous administration of R-IB or S-IB

Results are expressed as the mean ± S.D. (n = 3).

ParameterControlAA
R-IBS-IBR-IBS-IB
V1 (ml/kg)90.1 ± 20.067.2 ± 9.8113 ± 3899.3 ± 18.3
V2 (ml/kg)78.5 ± 29.293.4 ± 72.2125 ± 52112 ± 69
CLtot (ml/min/kg)4.28 ± 0.191.26 ± 0.12b6.87 ± 1.05a2.83 ± 0.92a, b
CLRS (ml/min/kg)2.21 ± 0.533.81 ± 0.42a
CLMET (ml/min/kg)2.07 ± 0.321.26 ± 0.12b3.05 ± 0.42a2.83 ± 0.92a
k0(R) (min−1)0.023 ± 0.0030.029 ± 0.009
k12 (min−1)0.026 ± 0.0180.056 ± 0.0300.029 ± 0.0100.058 ± 0.020
k21 (min−1)0.031 ± 0.0180.046 ± 0.0200.033 ± 0.0130.050 ± 0.017
k10 (min−1)0.048 ± 0.0080.019 ± 0.004b0.060 ± 0.0080.028 ± 0.006b
kRS (min−1)0.026 ± 0.0110.032 ± 0.003
  • a P < 0.05 compared with controls.

  • b P < 0.05 compared with its antipode.

  • The em dashes indicate no value because of unidirectional chiral inversion of IB.