Estimated metformin and 1-NMN pharmacokinetic parameters throughout gestation
Results are reported as mean ± S.D. The subject characteristics for early, mid, and late pregnancy were compared with postpartum.
| Early-Pregnancy (10–14 weeks gestation) | Mid-Pregnancy (22–26 weeks gestation) | Late-Pregnancy (34–38 weeks gestation) | Postpartum ≥12 weeks | |
|---|---|---|---|---|
| Number of subjects | 6 | 15 | 13 | 14 |
| Creatinine clearance (ml/min) | 188 ± 55 | 235 ± 66** | 217 ± 63* | 159 ± 44 |
| Metformin | ||||
| Metformin CLR (ml/min) | 542 ± 200 | 775 ± 252** | 653 ± 166** | 467 ± 131 |
| Metformin CLsec (ml/min) | 354 ± 186 | 538 ± 202** | 438 ± 110** | 304 ± 95 |
| 1-NMN | ||||
| 1-NMN Css,ave (nM) | 188 ± 55 | 205 ± 121 | 230 ± 101 | 184 ± 135 |
| 1-NMN CLR (ml/min) | 215 ± 94 | 504 ± 293** | 557 ± 305** | 240 ± 106 |
| 1-NMN CLsec (ml/min) | 42 ± 67 | 269 ± 267* | 342 ± 283** | 76 ± 92 |
CLR, renal clearance; CLsec, renal secretion clearance.
↵* P < 0.05, **P < 0.01 for comparisons to postpartum.