Summary of human P450 splice variants
| Enzyme Family | Transcript Size | Exons | Amino Acids | Mol. Weight | Variant RNAs | SNPs | Disease Links | Ratio of Viable Protein |
|---|---|---|---|---|---|---|---|---|
| Gene no. | Nucleotides | kDa | Total no. | Total no. | Total | |||
| CYP1 (3) | 2683–5988 | 3–7 | 512–543 | 58.2–60.8 | 49a | 1052 | 203 | 0.64b (31) |
| CYP2 (16) | 1681–5024 | 5–9 | 491–596 | 55.7–67.6 | 281 | 11853 | 413 | 0.50 (141) |
| CYP3 (4) | 1604–2167 | 13–14 | 502–534 | 57.1–61.3 | 120 | 3029 | 93 | 0.47 (56) |
| CYP4 (12) | 1678–3395 | 5–16 | 505–638 | 59.1–71.3 | 170 | 9725 | 37 | 0.53 (90) |
| CYP5 (1) | 2093 | 13 | 594 | 66.9 | 30 | 5274 | 6 | 0.48 (14) |
| CYP7 (2) | 2765–2950 | 6 | 504–506 | 57.7–58.3 | 4 | 3688 | 35 | 0.80 (3) |
| CYP8 (2) | 3974–5632 | 1–10 | 501–527 | 58.1–59.5 | 9 | 1752 | 16 | 0.77 (7) |
| CYP11 (3) | 2311–3558 | 9 | 503–521 | 57.6–60.1 | 52 | 1807 | 74 | 0.57 (30) |
| CYP17 (1) | 2001 | 8 | 508 | 57.4 | 13 | 179 | 31 | 0.57 (7) |
| CYP19 (1) | 4479 | 10 | 503 | 57.9 | 47 | 2178 | 45 | 0.57 (27) |
| CYP20 (1) | 1811 | 13 | 470 | 53.4 | 21 | 1308 | 1 | 0.54 (11) |
| CYP21 (1) | 2153 | 10 | 495 | 56.0 | 30 | 91 | 35 | 0.52 (16) |
| CYP24 (1) | 3266 | 12 | 514 | 58.9 | 17 | 711 | 19 | 0.46 (8) |
| CYP26 (3) | 1569–4536 | 6–7 | 497–522 | 56.2–57.5 | 23 | 858 | 22 | 0.68 (16) |
| CYP27 (3) | 2579–5117 | 8–9 | 372–531 | 42.6–60.2 | 55 | 1582 | 58 | 0.58 (32) |
| CYP39 (1) | 2623 | 12 | 469 | 54.1 | 15 | 2179 | 2 | 0.50 (8) |
| CYP46 (1) | 2186 | 15 | 500 | 56.8 | 11 | 952 | 7 | 0.57 (6) |
| CYP51 (1) | 2817 | 6 | 860 | 98.0 | 18 | 388 | 2 | 0.65 (12) |
| Total 57 | 1569–5632 | 1–16 | 372–860 | 42.6–98.0 | 965 | 48,384 | 1097 | 0.534 (515) |
↵a Total number of variant RNA transcripts represents the total of all nonredundant transcripts identified for human P450 forms in the AceView, Ensembl, and PubMed databases. Transcripts with the same predicted protein molecular weight (in kDa) with a fewer than four base-pair differences in nucleotide transcript length were considered the same transcript. Data for SNPs was obtained from GeneCards.org, and Disease Links were obtained from the MalaCards.org.
↵b Ratio of viable protein represents the fraction of human P450 variant transcripts predicted to code functional proteins using the highest confidence scoring metrics for the AceView (very good) and ENSEMBL (Protein coding/merged Ensembl/Havana). Total number of predicted variant proteins indicated in parenthesis.