TABLE 5

Pefloxacin and metabolites identified and amounts eliminated as percent dose in bile, urine, and feces after a single 25-mg/kg oral dose administration of [14C]pefloxacin to male Sprague-Dawley rats

Pefloxacin/
MetaboliteProposed StructurePercent Dose Eliminated
BileUrineFecesTotal
PefloxacinPefloxacin1.874.9512.8619.68
M1Norfloxacin glucuronideBQL0.13BQL0.13
M2Norfloxacin glucuronide1.18BQLBQL1.18
M3Pefloxacin + O glucuronide0.08BQLBQL0.08
M4Pefloxacin glucuronide32.943.32BQL36.26
M5Pefloxacin glucuronide1.550.19BQL1.74
M6Desethyl-pefloxacin + 2H0.531.180.312.02
M7Norfloxacin0.196.091.307.58
M8Pefloxacin + O1.805.710.137.64
M9Norfloxacin + O −2HBQLBQL0.060.06
Total eliminated86.84
Total identified76.31