TABLE 3

Percent dose eliminated in urine, bile, and feces after a single 25-mg/kg oral dose of [¹⁴C]pefloxacin or pefloxacin to male bile-cannulated Sprague-Dawley rats

Matrix	Collection Interval	Percent Dose Eliminated
Matrix	Collection Interval	Radioactivity^a	¹⁹F NMR^b
Urine	0–24 h	22.81	26.57
Bile	0–12 h	44.76	39.41
Feces	0–48 h	19.27	15.81
Total	NA	86.84	81.79

NA, not applicable.
↵^a Values represent mean (n = 4).
↵^b Values represent single determination (a known amount of sample from n = 4 animals were pooled for each matrix before analysis).