Percent dose eliminated in urine, bile, and feces after a single 25-mg/kg oral dose of [14C]pefloxacin or pefloxacin to male bile-cannulated Sprague-Dawley rats

MatrixCollection IntervalPercent Dose Eliminated
Radioactivitya19F NMRb
Urine0–24 h22.8126.57
Bile0–12 h44.7639.41
Feces0–48 h19.2715.81
  • NA, not applicable.

  • a Values represent mean (n = 4).

  • b Values represent single determination (a known amount of sample from n = 4 animals were pooled for each matrix before analysis).