TABLE 2

Cholestasis classification

Cholestasis ClassDrug Compounds
Common (>2%)Bosentan (1000 mg BID), cyclosporine A, erythromycin, imatinib
Rare (≤2%)Atazanavir, atorvastatin, bosentan (125 mg BID), glibenclamide, ibuprofen, ketoconazole, pitavastatin, pravastatin, verapamil
No cholestasisCerivastatin, fluvastatin, lovastatin acid, rosiglitazone, rosuvastatin, simvastatin acid
  • Bosentan was assigned to the classes “common” and “rare” depending on the administered dose [1000 and 125 mg twice daily (BID), respectively]. Literature references and detailed annotations are summarized in Supplemental Table 4.