Physiologic values used for CLR,met,UGT predictions using IVIVE in different scenarios

Parameter (U)Scenario 1 (Whole Kidney)Scenario 2 (Kidney Cortex)
MPPGK (mg/g kidney)11.1aDonor specificb
Kidney weight (g/kg body weight)4.53.1
Renal blood flow (ml/min/kg body weight)16.413.2
  • a Weighted (by number of donors) mean of values reported for microsomes prepared from mixed kidney or unspecified region (Al-Jahdari et al., 2006; Knights et al., 2016).

  • b Fig. 5 and (Supplemental Table S3).