TABLE 2

In vivo rat i.v. infusion study for determination of liver-to-plasma Kpuu

CompoundsPlasma Concentration at Terminal Time Point (ng/ml)Liver Concentration at Terminal Time Point (ng/ml)Total Liver-to-Plasma Ratio (Kp)Rat Plasma fu,pRat Liver fu,liverIn Vivo Rat Liver-to-Plasma Kpuu
Cerivastatin261 ± 706717 ± 96027 ± 8.00.016 ± 0.0010.017 ± 0.00129 ± 8.5
Fluvastatin245 ± 348990 ± 149037 ± 7.40.011 ± 0.0010.013 ± 0.00144 ± 8.7
Rosuvastatin14 ± 3.7178 ± 5013 ± 2.20.044 ± 0.0090.19 ± 0.0257 ± 9.5
Pravastatin33 ± 19171 ± 156.7 ± 4.50.54 ± 0.020.18 ± 0.022.2 ± 1.5
PF-04991532172 ± 671170 ± 3647.1 ± 2.00.12 ± 0.010.096 ± 0.025.7 ± 1.6
PF-0518796576 ± 21323 ± 134.4 ± 1.00.27 ± 0.010.15 ± 0.022.4 ± 0.57