Pharmacokinetic parameters for fexofenadine in garlic-, ginkgo-, and SJW-treated rats following an i.v. administration of fexofenadine (10 mg/kg); data represent mean ± S.E.M. (n = 6)
| Parameter | Control | Garlic | Ginkgo | SJW |
|---|---|---|---|---|
| AUC0–∞ (min × µg/mL) | 223 ± 14 | 246 ± 24 | 219 ± 12 | 173 ± 12* |
| t1/2 (h) | 1.2 ± 0.1 | 1.3 ± 0.1 | 1.3 ± 0.1 | 1.3 ± 0.1 |
| CL (mL/min) | 15.4 ± 1.0 | 14.4 ± 1.5 | 15.9 ± 1.0 | 19.7 ± 1.7* |
| Vss (L/kg) | 0.56 ± 0.1 | 0.44 ± 0.1 | 0.43 ± 0.1 | 0.58 ± 0.1 |
t1/2, half-life; Vss, volume of distribution at steady state.
↵* p < 0.05 versus control group.