TABLE 3

Influence of garlic, ginkgo, and SJW administration on the pharmacokinetic parameters of fexofenadine in the isolated perfused rat liver (mean ± S.E.M., n = 7)

Parameter	Control	SJW	Ginkgo	Garlic
AUC_0–60 (min × µg/mL)	37.9 ± 2.8	27.9 ± 2.2	29.2 ± 2.4	33.1 ± 2.0
AUC_0–∞ (min × µg/mL)	43.3 ± 2.8	29.9 ± 3.2	31.6 ± 3.3	36.9 ± 2.9
CL (mL/min)	11.9 ± 0.86	17.6 ± 1.37^*	16.8 ± 1.58^*	1 13.8 ± 0.77
Ae_0–60 (µg)	95 ± 3	234 ± 12^*	157 ± 18^*	141 ± 15^*
CL_b,p (mL/min)	2.61 ± 0.25	8.71 ± 0.82^*	5.76 ± 0.93^*	4.46 ± 0.62^*
CL_b,l (mL/min)	0.11 ± 0.03	0.18 ± 0.06^*	0.11 ± 0.03	0 0.11 ± 0.04
B/L	17.3 ± 1.4	22.4 ± 2.7	15.5 ± 2.3	15.6 ± 1.8
L/P	83 ± 5	266 ± 45^*	219 ± 32^*	150 ± 20^*

↵* p < 0.05 versus control group.