In vitro Kp and Kpuu between cells and media in rat suspension hepatocytes
| Compounds | fu,media | fu,cella | Kp | Kpuu |
|---|---|---|---|---|
| Cerivastatin | 0.022 ± 0.003 | 0.017 ± 0.001 | 27 ± 2.6 | 21 ± 2.0 |
| Fluvastatin | 0.016 ± 0.001 | 0.013 ± 0.001 | 27 ± 1.8 | 22 ± 1.5 |
| Rosuvastatin | 0.19 ± 0.02 | 0.19 ± 0.02 | 35 ± 0.6 | 35 ± 0.6 |
| Pravastatin | 0.49 ± 0.06 | 0.18 ± 0.02 | 8.3 ± 0.8 | 3.0 ± 0.3 |
| PF-04991532 | 0.12 ± 0.01 | 0.096 ± 0.02 | 8.9 ± 0.1 | 7.1 ± 0.1 |
| PF-05187965 | 0.36 ± 0.01 | 0.15 ± 0.02 | 10 ± 0.4 | 4.2 ± 0.2 |
↵a Fu,cell is assumed to be the same as fu,liver in Table 2, because 80% of the liver is made of hepatocytes by volume (Bayliss and Skett, 1996).