Fexofenadine pharmacokinetics in garlic-, ginkgo-, and SJW-treated rats following an oral administration of fexofenadine (100 mg/kg); data represent mean ± S.E.M. (n = 5)
| Parameter | Control | Garlic | Ginkgo | SJW |
|---|---|---|---|---|
| AUC0–∞ (min × µg/mL) | 28.8 ± 3.8 | 42.3 ± 6.2* | 29.2 ± 3.8 | 25.9 ± 3.4 |
| t1/2 (h) | 2.4 ± 0.3 | 2.7 ± 0.4 | 2.5 ± 0.2 | 2.7 ± 0.7 |
| Cmax (min) | 240 ± 49 | 444 ± 89* | 191 ± 51 | 133 ± 22 |
| Tmax (min) | 9 ± 1 | 8 ± 2 | 17 ± 5 | 24 ± 10 |
| F (%) | 1.29 ± 0.17 | 1.72 ± 0.25 | 1.33 ± 0.17 | 1.50 ± 0.20 |
Cmax, maximum plasma concentration; F, bioavailability; t1/2, half-life; Tmax, time to maximum plasma concentration.
↵* p < 0.05 versus control group.