TABLE 5

IC50 values of uremic toxins on the inhibition of morinidazole conjugates uptake in OAT expressed HEK293 cells

Data are expressed as mean ± S.D., n = 3.

SubstrateTransporterIC50 values of inhibitors (μM)
ISCMPFHAIAA
M7OAT1200 ± 42187 ± 22162 ± 17197 ± 26
M7OAT3222 ± 2819.2 ± 1.387.4 ± 6.0404 ± 33
M8-1OAT3161 ± 388.53 ± 0.3139.4 ± 1.8181 ± 7
M8-2OAT378.3 ± 12.76.75 ± 1.7624.1 ± 2.3173 ± 33