Pharmacokinetic parameters of M7 after an intravenous administration of 15 mg/kg M7 to control (n = 9) and 5/6 Nx (n = 13) rats
Data are expressed as mean ± S.D.
| Parameter | Control rats (n = 9) | 5/6 Nx rats (n = 13) |
|---|---|---|
| Cmax (μg/ml) | 24.7 ± 6.4 | 51.9 ± 7.4a |
| tmax (h) | 0.08 ± 0.00 | 0.08 ± 0.00 |
| t1/2 (h) | 0.27 ± 0.05 | 0.93 ± 0.29a |
| AUC0–t (μg·h/ml) | 7.83 ± 1.71 | 28.3 ± 6.9a |
| AUC0–∞ (μg·h/ml) | 7.87 ± 1.71 | 28.5 ± 6.9a |
| CL (l/h/kg) | 1.98 ± 0.41 | 0.55 ± 0.11a |
| Vss (l/kg) | 0.40 ± 0.15 | 0.33 ± 0.08 |
| MRT (h) | 0.20 ± 0.05 | 0.61 ± 0.17a |
AUC0–∞, area under the concentration-time curve from 0 hour to the infinite time; CL, total body clearance; Cmax, maximum plasma concentration; tmax, time to the Cmax; t1/2, apparent elimination half-life; MRT, mean residence time; VSS, volume of distribution at steady state.
↵a P < 0.001 compared with control.