Parameter | Dose | ||
---|---|---|---|
0.1 | 1.5 | 15 | |
mg/kg | |||
Cmax (μg/ml) | 0.0820 ± 0.0122 | 1.53 ± 0.15 | 14.1 ± 2.7 |
tmax (h) | 0.08 ± 0.00 | 0.08 ± 0.00 | 0.08 ± 0.00 |
t1/2 (h) | 0.26 ± 0.05 | 0.22 ± 0.03 | 0.24 ± 0.02 |
AUC0–t (μg·h/ml) | 0.0233 ± 0.0039 | 0.426 ± 0.043 | 4.09 ± 0.72 |
AUC0–∞ (μg·h/ml) | 0.0235 ± 0.0039 | 0.427 ± 0.043 | 4.10 ± 0.72 |
CL (l/h/kg) | 4.36 ± 0.76 | 3.54 ± 0.34 | 3.75 ± 0.69 |
Vss (l/kg) | 0.63 ± 0.09 | 0.45 ± 0.04 | 0.58 ± 0.15 |
MRT (h) | 0.15 ± 0.02 | 0.13 ± 0.01 | 0.16 ± 0.02 |
AUC0–∞, area under the concentration-time curve from 0 hour to the infinite time; CL, total body clearance; Cmax, maximum plasma concentration; tmax, time to the Cmax; t1/2, apparent elimination half-life; MRT, mean residence time; VSS, volume of distribution at steady state.