TABLE 4

Pharmacokinetic parameters of M7 with intravenous administration of different dose in normal rats

Data are expressed as mean ± S.D., n = 4.

ParameterDose
0.11.515
mg/kg
Cmax (μg/ml)0.0820 ± 0.01221.53 ± 0.1514.1 ± 2.7
tmax (h)0.08 ± 0.000.08 ± 0.000.08 ± 0.00
t1/2 (h)0.26 ± 0.050.22 ± 0.030.24 ± 0.02
AUC0–t (μg·h/ml)0.0233 ± 0.00390.426 ± 0.0434.09 ± 0.72
AUC0–∞ (μg·h/ml)0.0235 ± 0.00390.427 ± 0.0434.10 ± 0.72
CL (l/h/kg)4.36 ± 0.763.54 ± 0.343.75 ± 0.69
Vss (l/kg)0.63 ± 0.090.45 ± 0.040.58 ± 0.15
MRT (h)0.15 ± 0.020.13 ± 0.010.16 ± 0.02
  • AUC0–∞, area under the concentration-time curve from 0 hour to the infinite time; CL, total body clearance; Cmax, maximum plasma concentration; tmax, time to the Cmax; t1/2, apparent elimination half-life; MRT, mean residence time; VSS, volume of distribution at steady state.