TABLE 4

Apparent kinetic transport parameters for methamphetamine, amphetamine, and p-OHMA for hMATE1 and hMATE2-K from simultaneously modeling active and passive accumulation

Results represent Mean ± S.D. of three independent experiments each run in triplicate (Fig. 5; Supplemental Fig. 5).

TransporterMethamphetamineAmphetaminep-OHMA
KmVmaxKmVmaxKmVmax
μMpmol/mg/minμMpmol/mg/minμMpmol/mg/min
hMATE120.6 ± 4.586.6 ± 5414.1 ± 4.9238 ± 14149.8 ± 26257 ± 190
hMATE2-K18.1 ± 1197.7 ± 25.316.4 ± 12.292.9 ± 8.5NANA
  • NA, not applicable.