TABLE 2

EC₅₀ values of methamphetamine and amphetamine for hOCT1 and hOCT2 determined by two-binding site fitting

The EC₅₀ values were obtained by fitting inhibition data in Fig. 1 and Supplemental Fig. 2 using eq. 2 described in Materials and Methods with the fit shown in Supplemental Fig. 3. The last column lists the P values obtained by comparing eqs. 1 and 2 with an extra sum-of-squares F test. Results represent mean ± S.D. of three independent experiments each run in triplicate.