Summary of model parameter estimates for rhTNF-α plasma PK
| Parameter | Definition | Estimate | CV |
|---|---|---|---|
| % | |||
| fd1 | Fraction of (QCO–Qk) for V1 | 0.6663 | 380 |
| fd2 | Fraction of (QCO–Qk) for V2 | 0.007463 | 18.5 |
| fdk | Fraction of Qk for Vk | 0.8 | Fixed |
| Kp | Partition coefficient | 0.5172 | 11.9 |
| V1 (ml) | ECF volume for tissue compartment 1 | 13.10 | 19.5 |
| Vmax (ng/h) | Michaelis Menten capacity constant | 3152 | 11.3 |
| Km (ng/ml) | Michaelis Menten affinity constant | 31.72 | 19.3 |
| GSC | Glomerular sieving coefficient | 0.1031 | 14.9 |
ECF, extracellular fluid.