Michaelis-Menten enzyme kinetic parameters for biotransformation of fevipiprant by UGT enzymes
| UGT1A3 | UGT2B7 | UGT2B17 | |
|---|---|---|---|
| Vmax (mean ± S.D., pmol/min/mg) | 5634 ± 1603 | 35.2 ± 6.8 | 43.3 ± 0.9 |
| Km (mean ± S.D., µM) | 13,352 ± 5854 | 320 ± 143 | 53.3 ± 4.5 |
| Derived intrinsic clearance (Vmax/Km, µl/mg/min) | 0.422 | 0.11 | 0.812 |