TABLE 1

PK parameters of total radioactivity in whole blood and plasma and of fevipiprant and its main circulating metabolite (AG metabolite) in plasma

Values are mean ± S.D.

Parameter	Total Radioactivity		Plasma
Parameter	Whole Blood	Plasma	Fevipiprant	AG Metabolite
T_max (h)^{^a}	3.00 (3.00−6.00)	3.00 (3.00−6.00)	2.50 (2.00−6.00)	3.00 (3.00−6.00)
C_max (ng/ml or ng-eq/ml)^b	923 ± 216	1750 ± 396	348 ± 139	1020 ± 247
AUC_{0−240 h} (ngh/ml or ng-eqh/ml)^c	36,400 ± 6960	76,500 ± 9740	2490 ± 312	6890 ± 1240
AUC_inf (ng-eq*h/ml)	69,700 ± 10,600	156,000 ± 20,700	—	—
CL/F (l/h)	—	—	80.5 ± 9.42	—
Vz/F (l)	—	—	1370 ± 459	—
T_1/2 (h)	230 ± 54.6	254 ± 24.8	12.3 ± 5.95	11.8 ± 5.19

↵^a T_max is presented as median (range).
↵^b Units are ng/ml for fevipiprant and AG metabolite, and ng-eq/ml for total radioactivity.
↵^c Units are ng*h/ml for fevipiprant and AG metabolite, and ng-eq*h/ml for total radioactivity.