TABLE 2

Fevipiprant and metabolites in plasma, based on metabolism profiles

Values are presented as mean ± S.D.

Component	[¹⁴C]-AUC_{0−12 h}^a
Component	ng/ml or ng-eq*h/ml^b	% of Total
Fevipiprant	1690 ± 266	15.3 ± 2.33
AG metabolite	6240 ± 922	56.5 ± 5.65
P8.5	125 ± 145	1.18 ± 1.37
Sum of additional components	47.1 ± 52.9	0.405 ± 0.426
Total components detected	8100 ± 852	73.4 ± 2.73
Lost during sample processing	2920 ± 210	26.6 ± 2.73
Total radiolabeled components in sample	11,000 ± 837	100

↵^a Calculated using the linear trapezoidal method; concentrations at time zero taken as zero.
↵^b Units are ng/ml for fevipiprant, and ng-eq/ml for other components.