Covalent binding of fevipiprant to microsomes and hepatocytes in vitro

Incubation ConditionsAmount of Covalent Drug Protein Adducts
HLM, GSH1 ± 0.0 pmol/mg protein
HLM, NADPH3 ± 0.4 pmol/mg protein
HLM, NADPH, UDPGA3 ± 0.3 pmol/mg protein
HLM, NADPH, UDPGA, GSH1 ± 0.5 pmol/mg protein
HH8 ± 1.4 pmol/106 cells
  • GSH, glutathione; HLM, human liver microsomes; HH, human hepatocytes; NADPH, nicotine adenine dinucleotide phosphate; UDPGA, uridine diphosphoglucuronic acid.