Covalent binding of fevipiprant to microsomes and hepatocytes in vitro
| Incubation Conditions | Amount of Covalent Drug Protein Adducts |
|---|---|
| HLM, GSH | 1 ± 0.0 pmol/mg protein |
| HLM, NADPH | 3 ± 0.4 pmol/mg protein |
| HLM, NADPH, UDPGA | 3 ± 0.3 pmol/mg protein |
| HLM, NADPH, UDPGA, GSH | 1 ± 0.5 pmol/mg protein |
| HH | 8 ± 1.4 pmol/106 cells |
GSH, glutathione; HLM, human liver microsomes; HH, human hepatocytes; NADPH, nicotine adenine dinucleotide phosphate; UDPGA, uridine diphosphoglucuronic acid.