TABLE 3

Fevipiprant and metabolites in excreta

Values are presented as mean ± S.D.

Component	Excretion (% of Dose)^{^a}			Excretion (% of Dose)^b
Component	Urine 0−72 h	Feces 0−96 h	Total	Urine 0−240 h
Fevipiprant	12.7 ± 2.21	44.5 ± 6.12	57.2 ± 6.29	11.0 ± 1.56
AG metabolite	26.9 ± 2.58	1.24 ± 0.244	28.1 ± 2.40	19.25 ± 2.48
Lactone metabolite	0.133 ± 0.0458	0.177 ± 0.355	0.310 ± 0.389	NA
P5.3	0.0956 ± 0.0121	0.00	0.0956 ± 0.0121	NA
Total components detected	39.8 ± 3.35	46.0 ± 6.36	85.7 ± 5.16	NA
Total excretion in time period^c	41.2 ± 3.78	50.5 ± 6.26	91.7 ± 4.97	NA

NA, not available.
↵^a Quantified from radioactivity profiles.
↵^b Quantified by LC-MS/MS.
↵^c The difference between total excretion and total components detected corresponds to losses during sample preparation.