Comparison of RIF IC50 values for inhibition of CP I, CP III, and RSV transport by hepatic OATP transporters
Data are expressed as means ± S.D. (n = 3).
| Transporter | RIF IC50 (μM) | ||
|---|---|---|---|
| CP I (0.2 μM) | CP III (0.2 μM) | RSV (Reference) | |
| OATP1B1 | 0.66 ± 0.11 | 0.79 ± 0.16 | 1.10 ± 0.28 (Shen et al., 2013);1.1 ± 0.2 (Prueksaritanont et al., 2014);0.95 ± 0.10 (Izumi et al., 2015); |
| OATP1B3 | 0.25 ± 0.03 | 0.27 ± 0.02 | 0.49 ± 0.13 (Shen et al., 2013); 0.3 ± 0.05 (Prueksaritanont et al., 2014); 0.2 ± 0.1 (Chu et al., 2015); |
| OATP2B1a | No uptake | 48.4 ± 7.6 | 89.8 ± 5.4 (Shen et al., 2013); 81 ± 34 (Prueksaritanont et al., 2014) |
↵a Significant uptake of CP III but not CP I by OATP2B1-HEK cells versus mock-HEK cells.