Effects of PB on hepatic hypertrophy in WT and Cyp2a(4/5)bgs-null mice
Liver weight and liver-to-body weight ratio were determined for 2- to 3-month-old WT and Cyp2a(4/5)bgs-null mice after PB or saline treatment. Data represent means ± S.D. (n=3 or 4).
Sex | Strain | Liver weight (g) | Liver-to-Body Weight Ratio | ||||
---|---|---|---|---|---|---|---|
Saline | PB | (PB-Saline)/Saline | Saline | PB | (PB-Saline)/Saline | ||
Male | WT | 1.47 ± 0.15 | 2.54 ± 0.27a | 73% | 0.048 ± 0.006 | 0.069 ± 0.004a | 47% |
Null | 1.25 ± 0.08 | 1.69 ± 0.25b,c | 35% | 0.046 ± 0.004 | 0.056 ± 0.002c | 22% | |
Female | WT | 1.04 ± 0.22 | 1.43 ± 0.13d | 38% | 0.045 ± 0.005 | 0.051 ± 0.004d | 13% |
Null | 1.13 ± 0.07 | 1.39 ± 0.08 | 23% | 0.046 ± 0.003 | 0.049 ± 0.003 | 6.5% |