TABLE 1.

Effects of PB on hepatic hypertrophy in WT and Cyp2a(4/5)bgs-null mice

Liver weight and liver-to-body weight ratio were determined for 2- to 3-month-old WT and Cyp2a(4/5)bgs-null mice after PB or saline treatment. Data represent means ± S.D. (n=3 or 4).

SexStrainLiver weight (g)Liver-to-Body Weight Ratio
SalinePB(PB-Saline)/SalineSalinePB(PB-Saline)/Saline
MaleWT1.47 ± 0.152.54 ± 0.27a73%0.048 ± 0.0060.069 ± 0.004a47%
Null1.25 ± 0.081.69 ± 0.25b,c35%0.046 ± 0.0040.056 ± 0.002c22%
FemaleWT1.04 ± 0.221.43 ± 0.13d38%0.045 ± 0.0050.051 ± 0.004d13%
Null1.13 ± 0.071.39 ± 0.0823%0.046 ± 0.0030.049 ± 0.0036.5%
  • a P < 0.01, compared with corresponding saline group (2-way ANOVA with Sidak's multiple comparisons posttest).

  • b P < 0.05, compared with corresponding saline group.

  • c P < 0.01, compared with corresponding WT group.

  • d P < 0.01, compared with corresponding male group.