TABLE 1

Pharmacokinetic parameters (mean ± S.D.) of [11C]erlotinib in EGFRfl/fl mice (n = 6) and in EGFR∆hep mice (n = 5)

AUC (min)AUC ratioakuptake (mL/min per g tissue)kbile (min−1)kurine (min−1)
LiverEGFRfl/fl1315 ± 2705.00 ± 0.620.799 ± 0.0760.018 ± 0.003
EGFR∆hep1783 ± 345*4.53 ± 0.290.720 ± 0.1510.006 ± 0.002***
KidneyEGFRfl/fl677 ± 1222.58 ± 0.260.458 ± 0.0480.021 ± 0.015
EGFR∆hep1197 ± 177***3.07 ± 0.34*0.434 ± 0.0530.046 ± 0.013*
  • a Organ-to-blood AUC ratio.

  • * P < 0.05; ***P < 0.001 compared with EGFRfl/fl (two-tailed unpaired t test).