TABLE 1

Fold change of gene expression in PCN: vehicle-treated rats

Values are fold change PCN to vehicle treated, ± S.D. Fold change between genotypes analyzed by one-way analysis of variance followed by Tukey’s multiple comparisons test.

P450 Gene	WT	PXR^−/−	CAR^−/−	PXR^−/−/CAR^−/−
Cyp2b2	2.42*	1.65	26.76	1.09
	(± 0.85)	(± 0.50)	(± 23.56)	(± 0.35)
Cyp3a23/3a1	5.30*	1.23**	8.08	1.24**
	(± 1.32)	(± 0.27)	(± 4.60)	(± 0.29)
Cyp3a18	3.78*	1.19**	4.86*	1.19**
	(± 1.23)	(± 0.24)	(± 2.22)	(± 0.13)
Cyp3a2	2.83*	1.25	2.58*	0.82
	(± 2.23)	(± 0.36)	(± 0.70)	(± 0.35)
Cyp3a9	2.89*	4.31*	2.07	1.24
	(± 0.84)	(± 2.03)	(± 1.06)	(± 0.33)
Slco1a2	3.30*	1.00**	3.82*	0.93**
	(± 1.13)	(± 0.20)	(± 1.01)	(± 0.15)
Slco1a1	1.34	0.81	0.65	0.64
	(± 0.55)	(± 0.37)	(± 0.08)	(± 0.13)
Slc10a1	1.06	1.06	0.94	0.85
	(± 0.36)	(± 0.21)	(± 0.25)	(± 0.14)
Ugt2b1	1.87	0.68	3.65^,*	0.62
	(± 0.62)	(± 0.18)	(± 0.97)	(± 0.17)
Ugt1a6	0.70	0.68	0.79	0.43
	(± 0.24)	(±0.13)	(± 0.21)	(± 0.07)
Sult2a2	5.71*	0.67**	5.04*	0.43**
	(± 1.91)	(± 0.18)	(± 1.35)	(± 0.12)
Ephx1	1.24	0.80	0.84	0.43
	(± 0.42)	(± 0.16)	(± 0.22)	(± 0.07)
Gstm4	0.82	0.70	0.64	0.93
	(± 0.28)	(± 0.14)	(± 0.17)	(± 0.15)

* P < 0.05, significantly different from vehicle treated, same genotype (t test); **P < 0.05, significantly different from WT (Tukey’s).