TABLE 2

Effect of PHA408 on hepatic mRNA expression in PXR (+/+) and PXR (−/−) mice

Results are reported relative to saline controls. Data are presented as percentage of mean ± S.E.M. of (n = 4–5) mice; *significant from saline; #significant from LPS. *,#P < 0.05; **P < 0.01.

Genes% Control in PXR (+/+)% Control in PXR (−/−)
IL-6369 ± 19**505 ± 51**
IL-1β96 ± 4090 ± 123
TNF-α84 ± 10840 ± 122#
iNOS110 ± 80116 ± 179
Socs3194 ± 61**69 ± 58#
Abcb1a28 ± 16**38 ± 20*,#
Abcb1b28 ± 22**77 ± 28#
Abcg2168 ± 7**33 ± 15*,#
Abcc259 ± 16*61 ± 12*
Abcc384 ± 1465 ± 12*
Abcb1156 ± 12*76 ± 13*,#
Slc10a1101 ± 1362 ± 15*,#
Slco2b190 ± 1769 ± 15*
Slco1a441 ± 19*40 ± 15*
Cyp3a11158 ± 10**80 ± 12#
PXR148 ± 1**
  • iNOS, inducible nitric oxide synthase.