Average individual ESF for predicted CLint,u according to fup and BDDCS classification for human hepatocytes and liver microsomes
Numbers in italic indicate the exclusion of a single compound in this class; numbers in bold indicate exclusion of two compounds from this group.
| Category | ESF | |||||
|---|---|---|---|---|---|---|
| 0.001–0.01 fup | 0.01–0.1 fup | 0.1–1 fup | ||||
| Log Average | n | Log Average | n | Log Average | n | |
| Hepatocytes | ||||||
| Total | 6.0 | 9 | 4.0 | 37 | 3.3 | 53 |
| Hepatocytes (BDDCS) | ||||||
| Class 1 | 2.1 | 2 | 5.8 | 13 | 3.5 | 42 |
| Class 2 | 8.2 | 7 | 4.1 | 23 | 13 | 4 |
| Class 3 | 0 | 0.032 | 1 | 0.61 | 5 | |
| Microsomes | ||||||
| Total | 5.6 | 7 | 2.1 | 35 | 2.6 | 39 |
| Microsomes (BDDCS) | ||||||
| Class 1 | 4.3 | 2 | 2.7 | 13 | 3.8 | 31 |
| Class 2 | 6.3 | 5 | 2.3 | 20 | 1.0 | 4 |
| Class 3 | 0 | 0.013 | 1 | 0.22 | 3 | |