TABLE 2 

Intrinsic clearance (CLint, microliters per minute per milligrams protein) obtained from incubations of VU238 (1 μM) or M1 (VU922, 1 μM) with hepatic S9 (2.5 mg/ml) of multiple species

Data represent means ± S.D. of triplicate determinations.

SpeciesVU238VU922 (M1)
Human1.48 ± 0.312n.d.
Cynomolgus12.1 ± 0.6432.00 ± 0.040
Rhesus5.15 ± 0.5371.44 ± 0.139
Rat13.7 ± 0.2652.19 ± 0.201
Mouse4.76 ± 0.386n.d.
Guinea pig1.89 ± 0.1803.40 ± 0.069
Minipig3.51 ± 0.306n.d.

  • n.d., not determined because of low substrate turnover.