PK Parametera | Panobinostat Alone | Panobinostat + KTZ | Geometric Mean Ratio (90% CI) | |
---|---|---|---|---|
Cmax ng/ml | Observedb (n = 14) | 18.52 (42.6) | 29.98 (93.3) | 1.6 (1.2–2.2) |
Predicted (n = 100) | 9.67 (146) | 16.5 (154) | 1.7 (1.6–1.8) | |
Prediction error (%)c | −48 | −45 | 6 | |
AUC0-∞ ng × h/ml | Observed (n = 11–12) | 133.0 (39.9) | 220.7 (54.6) | 1.8 (1.5–2.2) |
Predicted (n = 100) | 225 (48) | 401 (48) | 1.8 (1.7–1.9) | |
Prediction error (%) | +69 | +82 | 0 |