Simcyp model-predicted pharmacokinetic parameters of MDZ administered as a single oral 5-mg dose on day 15 with and without multiple administration of panobinostat 20 mg three times a week (Monday, Wednesday, Friday) for 2 weeks
| PK Parametera | MDZ Alone | MDZ+ Panobinostat | Geometric Mean Ratio (90% CI) | |
|---|---|---|---|---|
| Cmax ng/ml | Predicted (n = 100) | 14.5 (57) | 15.1 (56) | 1.04 (1.03–1.04) |
| AUC0-∞ ng × h/ml | Predicted (n = 100) | 56.2 (64) | 58.7 (64) | 1.04 (1.04–1.05) |
↵a Values are the geometric mean (CV%).